Medicines to treat high blood pressure or heart failure such as beta-blockers, clonidine, guanethidine and reserpine. These can also hide the signs of hypoglycaemia, so special care is needed when taking these medicines Colesevelam, a medicine used to reduce cholesterol, has an effect on the absorption of Amaryl. To avoid this effect, you should be advised to take Amaryl at least 4 hours before colesevelam. Alcohol intake may increase or decrease the blood sugar lowering action of Amaryl in an unpredictable way. Amaryl should not be taken during pregnancy. Tell your doctor if you are, you think you might be or are planning to become pregnant. Your ability to concentrate or react may be reduced if your blood sugar is lowered hypoglycaemia, or raised hyperglycaemia or if you develop visual problems as a result of such conditions. Bear in mind that you could endanger yourself or others e.g. when driving a car or using machines. Please ask your doctor whether you can drive a car if you: If you have been told by your doctor that you cannot tolerate some sugars, contact your doctor before taking this medicine. Always take this medicine exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Take this medicine by mouth, just before or with the first main meal of the day usually breakfast. If you do not have breakfast you should take the medicine on schedule as prescribed by your doctor. It is important not to leave out any meal when you are on Amaryl The dose of Amaryl depends on your needs, condition and results of blood and urine sugar tests and is determined by your doctor. Do not take more tablets than your doctor has prescribed. A combination therapy of glimepiride plus metformin or of glimepiride plus insulin may be started. In such a case your doctor will determine the proper doses of glimepiride, metformin or insulin individually for you Your dose of Amaryl may need to be adjusted if you change weight, change your lifestyle, or if you are under a lot of stress. Please speak to your doctor if any of these situations apply to you. If you feel the effect of your medicine is too weak or too strong do not change the dose yourself, but ask your doctor. If you happen to have taken too much Amaryl or an additional dose there is a danger of hypoglycaemia signs of hypoglycaemia see section 2 and therefore you should instantly consume enough sugar e.g. a small bar of sugar cubes, sweet juice, sweetened tea and inform a doctor immediately. When treating hypoglycaemia due to accidental intake in children, the quantity of sugar given must be carefully controlled to avoid the possibility of producing dangerous hyperglycaemia. Persons in a state of unconsciousness must not be given food or drink. Since the state of hypoglycaemia may last for some time it is very important that the patient is carefully monitored until there is no more danger. Admission into hospital may be necessary, also as a measure of precaution. Show the doctor the package or remaining tablets, so the doctor knows what has been taken.